What is Ubenimex?

Ubenimex (INN), aswell accepted as bestatin, is a aggressive protease inhibitor. It is an inhibitor of
aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is getting advised for use in the analysis of
astute myelocytic leukemia.

Ubenimex is a aggressive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of
all the corpuscle curve except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were awful sensitive,
with 50% advance inhibitory concentrations (IC50) abutting to the best serum absorption if bestatin was orally
administered at 30 mg in analytic application. All corpuscle curve except for K562 awful bidding CD13, but a
bright alternation amid the acuteness to bestatin and announcement of CD13 was not observed. Other
aminopeptidase inhibitors such as amastatin A, arphamenine B and WM15 antibiotic showed no advance inhibitory
effects.

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