What is Tranilast?

Appearance: Yellow solid

Formulation: N/A

CAS Number: 53902-12-8

Molecular Formula: C₁₈H₁₇NO₅

Molecular Weight: 327.33

Tranilast is an angiogenesis inhibitor that aswell inhibits the absolution of histamine and prostaglandins from basophils and mast cells. Other functions of Tranilast cover the adeptness to arrest leukotrienes, oxygen radicals, cyclooxygenase-2 expression, cytokines, collagen synthesis, and blocks the assembly of IL-1 and IL-2 from animal T-cells and macrophages. Studies announce that Tranilast blocks vascular deepening and disrupts the NF-κB/CBP interaction, which leads to the inhibition of NF-κB abased archetype activation. Additionally, Tranilast has been appear to arrest the absolution of PGE2 and TGF-β from monocytes-macrophages and the transformation of fibroblasts to myofibroblasts, and abbreviating in vitro. Bland beef corpuscle studies accept appear that Tranilast inhibits vascular bland beef corpuscle growth, calcium entry, and acts as an adversary of Angiotensin (angiotensin II).


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: