CAS Number: 50-22-6
Molecular Weight: 346.46
Molecular Formula: C21H30O4
Appearance: Crystalline powder
Solubility: Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.
Storage: Store at room temperature
Application: Corticosteroid is an activator of MCR.
Corticosterone is a hormone actinic in acknowledgment to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which after-effects in adapted expression. This eventually affects ionic conductances through the membrane. Corticosterone induces apoptosis in murine cartilage marrow.
From Rhizoma Picrorhizae extract Picroside II have, namely how to eat vanilla acyl alcohol (Vanilloylcatalpol), prove its hepatoprotective effects on CCl4 induced hepatic toxicity for mice, beneficial effect on rats.
From picrorhiza petroleum ether extract were acetovanillone (Apocynirie), demonstrated the choleretic effect on rabbit. The separation of the mixture of Picroside from picrorhiza ethanol (Kutkin), to the oral administration of 3-50mg/kg rats, the serum and liver biochemical changes can dose dependently prevented the thioacetyl glue 3 chemicals induced rat, in better than milk thistle. Picroside cholagogue effect dose dependent and bile antagonistic ethinyl estradiol blocking effect in anesthetized and awake rats and guinea pigs.
Generations of herbal medicine and Chinese materia medica books, said its “toxic”, clinical application for 30 years, I did not find eupolyphaga toxic effects, but in more than ten cases of allergic reaction to the whole body itch, characterized by bright red skin lesions or dense small papules, this may be caused by opposite sex ground beetle contains protein, but usually after discontinuation 1-2 days can disappear, large doses (more than 30 grams) with nausea vomiting, dizziness, abdominal pain and other symptoms.
Take ground beetle bug may appear allergic reaction, the whole body with little pimples, itching, 1 — 2 days after drug withdrawal rash can disappear. But then take コ reverend mother ping liang, will be the same skin reaction. It may be that members of the opposite sex that its contain protein. On the digestive tract has certain stimulative. Also the use of this product for the amount were sinus heart rate slow response report.