Mannitol mechanism of action

Mannitol is an osmotic diuretic that is metabolically apathetic in bodies and occurs naturally, as a amoroso or amoroso alcohol, in fruits and vegetables. Mannitol elevates claret claret osmolality, consistent in added breeze of baptize from tissues, including the academician and cerebrospinal fluid, into interstitial aqueous and plasma. As a result, bookish edema, animated intracranial pressure, and cerebrospinal aqueous aggregate and burden may be reduced. As a diurectic mannitol induces diuresis because it is not reabsorbed in the renal tubule, thereby accretion the osmolality of the glomerular filtrate, facilitating elimination of water, and inhibiting the renal tubular reabsorption of sodium, chloride, and added solutes. Mannitol promotes the urinary elimination of baneful abstracts and protects adjoin nephrotoxicity by preventing the absorption of baneful substances in the tubular fluid. As an Antiglaucoma abettor mannitol levates claret claret osmolarity, consistent in added breeze of baptize from the eye into claret and a consistent abridgement in intraocular pressure. As a renal action analytic aid mannitol is advisedly filtered by the glomeruli with beneath than 10% tubular reabsorption. Therefore, its urinary elimination amount may serve as a altitude of glomerular filtration amount (GFR).

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