Drospirenone Pharmacology


Drospirenone differs from added constructed progestins in that its pharmacological contour in preclinical studies shows it to be afterpiece to the accustomed progesterone. As such it has almighty antimineralocorticoid properties, counteracts the estrogen-stimulated action of the renin-angiotensin-aldosterone system, and has aswell been apparent to acquire balmy antiandrogen activity.

The antimineralocorticoid backdrop apparent by drospirenone advance sodium elimination and anticipate baptize retention.


Drospirenone is taken orally with about 76% bioavailability. It is apprenticed not by sex hormone-binding globulin or corticosteroid bounden globulin, but by added serum proteins. Metabolites accept not been apparent to be biologically active, appearance up in urine and feces, and are about absolutely excreted aural 10 days.


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