The difluprednate chrism conception activate by suspending DFBA in a array of oils (castor, cottonseed, medium-chain blubbery acid triglyceride, oleic, olive, peanut, and soybean). Difluprednate ophthalmic emulsion’s alive metabolite, 6α,9-difluoroprednisolone 17-butyrate (DFB), has the everyman Ki amount (611 nM) for the glucocorticoid receptor and is decidedly added alive than prednisolone, which has a Ki amount of 3.4 nM.
Difluprednate chrism is rapidly deacetylated in the aqueous amusement to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug’s alive metabolite, which has a agnate corticosteroid action profile. Radio-labeled difluprednate is absolute in the appropriate eyes of bistered rabbits in a abstracted abstraction analytical DFBA excretion. Difluprednate (0.05% emulsion) after-effects in college aqueous amusement concentrations than the abeyance anatomy in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically cogent inhibition of deepening compared to acrid in a aerial model, with the anti-inflammatory acknowledgment proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three absorption (0.002%, 0.01%, and 0.05%) in a dose-dependent address in rats, and difluprednate 0.05% shows statistically above anti-inflammatory action compared to Betamethasone (0.1%).