Chloramphenicol is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thereby inhibiting bacterial protein synthesis.
Chloramphenicol is able-bodied captivated orally. Parenteral analysis should be IV.
Chloramphenicol is broadcast broadly in physique fluids, including CSF, and is excreted in urine. Because of hepatic metabolism, alive chloramphenicol does not accrue if renal dearth is present.
Use of chloramphenicol during abundance after-effects in fetal biologic levels about as top as affectionate levels. Gray babyish affection is a abstract concern, decidedly abreast term, but there is no bright affirmation of fetal risk.
Chloramphenicol enters breast milk. Safety during breastfeeding has not been determined.