Cefetamet pivoxil is an oral, third-generation cephalosporin whose ample spectrum of antibacterial action and favorable pharmacokinetic contour accomplish it decidedly acceptable for the analysis of a advanced ambit of communicable diseases. Cefetamet has top in vitro action adjoin both gram-positive and gram-negative bacilli that could cause a amount of respiratory amplitude and urinary amplitude infections. These cover penicillin-sensitive Streptococcus pneumoniae, Streptococcus spp, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus spp., Klebsiella spp. and Neisseria gonorrhoeae. It is not alive adjoin staphylococci, enterococci, Pseudomonas spp. or Bacteroides fragilis but does arrest a lot of bile-sensitive (oral) Bacteroides spp. Animal toxicology studies announce that neither cefetamet pivoxil nor the alive admixture cefetamet accept cogent teratogenic, mutagenic, photogenic or allergenic potential. Cefetamet is alone banausic in the urine with a half-life of 2.2 h. Volume of administering approximates the extracellular aqueous amplitude (0.3 1/kg), protein bounden is minima (22%) and articulate bioavailability of cefetamet pivoxil is about 50% if taken with food. No cogent biologic interactions accept been acclaimed to date.
The ability and tolerability of cefetamet pivoxil accept been evaluated in the analysis of gram-positive and gram-negative infections in about 5,000 patients. In allusive studies, cefetamet pivoxil was at atomic as effective, and in abounding cases clinically superior, to a lot of currently recommended antibiotics for the analysis of urinary amplitude infections including gonorrhea and complicated infections in top accident patients. Ability has aswell been approved in astute exacerbations of abiding bronchitis, pneumonia and infections of the ear, adenoids and throat. Analytic trials accept apparent that a 7 day analysis aeon with cefetamet pivoxil is as able as a 10 day advance of phenoxymethylpenicillin in the analysis of pharyngotonsillitis. Cefetamet pivoxil has been well-tolerated in analytic trials with alone 1.2% of patients on accepted doses alternate analysis prematurely. The a lot of accepted adverse furnishings are gastrointestinal (diarrhea, nausea, vomiting) which action in beneath than 10% of patients.
Many accepted antibacterial analysis regimens absorb the administering of three or added circadian doses. However, accepted doses of cefetamet pivoxil 500 mg alert circadian accommodate absolved claret concentrations of cefetamet which about beat the MIC90 for affected bacilli throughout the dosing breach and accept been approved to be clinically effective. This should aftereffect in acceptable acquiescence with analysis in out-patients. Dosing regimens for cefetamet pivoxil should be adapted in patients with broken renal action while accepted doses can be accustomed to aged patients and those with alarmist disease. Accepted doses in accouchement are 10 mg/kg or alternatively, accouchement may accept a dosage bargain in admeasurement to the arrangement of their physique apparent breadth to that of an adult.