Dutasteride is a constructed 4-azasteroid admixture that is a careful inhibitor of both the blazon 1 and blazon 2 isoforms of steroid 5 alpha-reductase (5AR), intracellular enzymes that catechumen testosterone to 5 alpha-dihydrotestosterone (DHT). Blazon I 5a-reductase is absolute in the sebaceous glands of a lot of regions of skin, including scalp, and liver. Blazon I 5a-reductase is amenable for about one-third of circulating DHT. The Blazon II 5a-reductase isozyme is primarily begin in prostate, seminal vesicles, epididymides, and hair follicles as able-bodied as liver, and is amenable for two-thirds of circulating DHT.
Dutasteride inhibits the about-face of testosterone to 5 alpha-dihydrotestosterone (DHT), which is the androgen primarily amenable for the antecedent development and consecutive amplification of the prostate gland. Testosterone is adapted to DHT by the agitator 5 alpha-reductase, which exists as 2 isoforms, blazon 1 and blazon 2. Dutasteride is a aggressive and specific inhibitor of both blazon 1 and blazon 2 5 alpha-reductase isoenzymes, with which it forms a abiding agitator complex. Dissociation from this circuitous has been evaluated beneath in vitro and in vivo altitude and is acutely slow. Dutasteride does not bind to the animal androgen receptor.