A hydroxylated metabolite of estradiol or estrone that has a hydroxyl accumulation at C3-beta, 16-alpha, and 17-beta position. Estriol is a above urinary estrogen. During pregnancy, ample bulk of estriol is produced by the placenta. Isomers with antagonism of the hydroxyl accumulation or groups are called epiestriol. Though estriol is used as allotment of the primarily North American abnormality of bioidentical hormone backup therapy, it is not accustomed for use by the FDA or Health Canada. It is about accessible in the United States by decree abounding alone by compounding pharmacies. It has aswell been accustomed and marketed throughout Europe and Asia for about 40 years for the analysis of post-menopausal hot flashes.
Estriol (also oestriol) is one of the three capital estrogens produced by the animal body. It is alone produced in cogent amounts during abundance as it is fabricated by the placenta. In abundant women with assorted sclerosis (MS), estriol reduces the disease’s affection noticeably, according to advisers at UCLA’s Geffen Medical School.