Tolcapone Pharmacokinetics

Tolcapone is rapidly captivated if accustomed orally and is rapidly alone with a beggarly half-life of about 2 hours. Tolcapone is metabolized to 3-O-methyl-tolcapone, which has an abolishment half-life of about 30 hours. Bioavailability of tolcapone is 60% afterward articulate administering due to aboriginal canyon metabolism. Tolcapone is about absolutely metabolized and excreted in urine and feces; glucuronidation is the a lot of important avenue of metabolism. No accession of tolcapone or its metabolite occurred if assorted doses of the biologic were accustomed to aged volunteers.


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