Marbofloxacin is a fluoroquinolone antimicrobial abettor developed alone for veterinary use. Marbofloxacin exhibits top antibacterial action adjoin a ample spectrum of aerobic Gram-negative and some Gram-positive bacteria, as able-bodied as Mycoplasma spp. As the third bearing fluoroquinolone, Marbofloxacin aswell mainly targets archetype and archetype enzymes such as DNA gyrase and topoisomerase IV, which are both essential for bacterial viability.
Marbofloxacin has a mycoplasmacidal effect during the exponential appearance but not during the lag phase, in both the M. hyopneumoniae 116 wild-type ache and a carbon abandoned 4 canicule post-marbofloxacin analysis in vivo at the ameliorative dose.
Marbofloxacin decidedly kills Leishmania promastigotes and intracellular amastigotes in a dose-dependent manner, added able than meglumine antimoniate and sodium stibogluconate. After analysis with Marbofloxacin, macrophages access attrition to infection and added antileishmanial action through the NO synthase pathway.